MolNFT v1 · #181000 · protein

Cryo-EM structure of E. COLI P pilus tip assembly intermediate papc- papd-papk-papg in the first conformation

7LHG · P fimbrial usher protein papc: “Cryo-EM structure of E. COLI P pilus tip assembly intermediate papc- papd-papk-papg in the first conformation”. Electron microscopy, 19 pockets (best druggability 0.86). MolNFT v1 #181000 on…

PDB: 7LHG
Type: protein
Length: 1,492 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: P fimbrial usher protein papc; Chaperone protein papd; Fimbrial adapter papk; P fimbria…
UniProt: A0A773A954, P15319, P62532, A0A798R8B8
Pockets: 19 · best druggability 0.86

Structure

electron microscopy · 4 distinct chains · 3% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C	P fimbrial usher protein papc	protein	805	3% helix, 46% strand	A0A773A954
D	Chaperone protein papd	protein	215	5% helix, 43% strand	P15319
K	Fimbrial adapter papk	protein	156	3% helix, 28% strand	P62532
G	P fimbria tip G-adhesin papg-II	protein	316	3% helix, 39% strand	A0A798R8B8

Pockets

19 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	939	0.86	0.87	131	empty
2	1176	0.85	0.86	136	empty
3	87	0.74	0.96	28	empty
4	368	0.70	0.82	52	empty
5	143	0.68	0.88	37	empty

Interfaces

6 interfaces between chains.

C–G · 4010 Å² buried · 40 hydrogen bonds · protein-protein
D–K · 2073 Å² buried · 34 hydrogen bonds · protein-protein
C–D · 1413 Å² buried · 15 hydrogen bonds · protein-protein
K–G · 1017 Å² buried · 19 hydrogen bonds · protein-protein
D–G · 380 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

7LHG · Cryo-EM structure of E. coli P pilus tip assembly intermediate PapC-PapD-PapK-PapG in the… · the same entry in another collection · chain C against C, TM-score 1.00
P15319 · AlphaFold monomer V2.0 prediction for chaperone protein papd (P15319) · a predicted model of the same protein · chain D against A, TM-score 0.96
P62532 · AlphaFold monomer V2.0 prediction for fimbrial adapter papk (P62532) · a predicted model of the same protein · chain K against A, TM-score 0.81

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A773A954
Every structure of UniProt P15319
Every structure of UniProt P62532
Every structure of UniProt A0A798R8B8
Elsewhere: RCSB PDB 7LHG · PDBe 7LHG · UniProt A0A773A954 · UniProt P15319 · UniProt P62532 · UniProt A0A798R8B8

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