MolNFT v1 · #180810 · protein
Crystal structure of the second bromodomain (BD2) of human BRD3 bound to ERK5-in-1
7LBT: “Crystal structure of the second bromodomain (BD2) of human BRD3 bound to ERK5-in-1”. X-ray diffraction, 1 ligand (VYJ). MolNFT v1 #180810 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7LBT
- Type
- protein
- Length
- 441 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q15059
- Ligands
- VYJ
Structure
x-ray diffraction · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | — | protein | 111 | — | Q15059 |
| B | — | protein | 109 | — | Q15059 |
| C | — | protein | 110 | — | Q15059 |
Ligands and binding sites
- VYJ · 11-cyclopentyl-2-({2-ethoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-5-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7LBT · Crystal structure of the second bromodomain (BD2) of human BRD3 bound to ERK5-IN-1 · the same entry in another collection · chain D against D, TM-score 1.00
- Q15059 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 3 (Q15059) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15059
- Elsewhere: RCSB PDB 7LBT · PDBe 7LBT · UniProt Q15059
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