MolNFT v1 · #180674 · protein
Alpha-synuclein fibrils
7L7H: “Alpha-synuclein fibrils”. Electron microscopy, 5 pockets (best druggability 0.66). MolNFT v1 #180674 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7L7H
- Type
- protein
- Length
- 352 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-synuclein
- UniProt
- P37840
- Pockets
- 5 · best druggability 0.66
Structure
electron microscopy · 1 distinct chain · 0% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H | Alpha-synuclein | protein | 44 | 0% helix, 14% strand | P37840 |
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 636 | 0.66 | 0.75 | 62 | empty |
| 2 | 607 | 0.64 | 0.75 | 60 | empty |
| 3 | 188 | 0.63 | 0.84 | 36 | empty |
| 4 | 136 | 0.56 | 0.82 | 36 | empty |
| 5 | 83 | 0.50 | 0.83 | 16 | empty |
Interfaces
13 interfaces between chains.
- B–C · 1708 Ų buried · 37 hydrogen bonds · protein-protein
- E–F · 1683 Ų buried · 34 hydrogen bonds · protein-protein
- C–D · 1678 Ų buried · 33 hydrogen bonds · protein-protein
- F–G · 1659 Ų buried · 31 hydrogen bonds · protein-protein
- G–H · 1658 Ų buried · 39 hydrogen bonds · protein-protein
Compared structures
- 7L7H · Alpha-synuclein fibrils · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37840
- Elsewhere: RCSB PDB 7L7H · PDBe 7L7H · UniProt P37840
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