MolNFT v1 · #180651 · protein
Unliganded elic in popc-only nanodiscs at 3.3-ångström resolution
7L6U · Gamma-aminobutyric-acid receptor subunit beta-1: “Unliganded elic in popc-only nanodiscs at 3.3-ångström resolution”. Electron microscopy, 20 pockets (best druggability 0.85). MolNFT v1 #180651 on GenesisL1: 3D structure, binding…
- PDB
- 7L6U
- Type
- protein
- Length
- 1,555 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gamma-aminobutyric-acid receptor subunit beta-1
- UniProt
- E0SJQ4
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 1 distinct chain · 33% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Gamma-aminobutyric-acid receptor subunit beta-1 | protein | 311 | 33% helix, 30% strand | E0SJQ4 |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 660 | 0.85 | 0.89 | 55 | empty |
| 2 | 795 | 0.80 | 0.83 | 83 | empty |
| 3 | 768 | 0.80 | 0.83 | 86 | empty |
| 4 | 919 | 0.79 | 0.81 | 89 | empty |
| 5 | 847 | 0.79 | 0.82 | 90 | empty |
Interfaces
10 interfaces between chains.
- C–D · 2463 Ų buried · 8 hydrogen bonds · protein-protein
- A–E · 2454 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 2443 Ų buried · 8 hydrogen bonds · protein-protein
- D–E · 2436 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 2423 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 7L6U · Unliganded ELIC in POPC-only nanodiscs at 3.3-Angstrom resolution · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E0SJQ4
- Elsewhere: RCSB PDB 7L6U · PDBe 7L6U · UniProt E0SJQ4
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