MolNFT v1 · #180641 · protein

APOL1 N-terminal domain

7L6K · Apolipoprotein L1: “APOL1 N-terminal domain”. Solution nmr, 2 pockets (best druggability 0.66). MolNFT v1 #180641 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7L6K
Type: protein
Length: 114 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Apolipoprotein L1
UniProt: O14791
Pockets: 2 · best druggability 0.66

Structure

solution nmr · 1 distinct chain · 65% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Apolipoprotein L1	protein	114	65% helix, 2% strand	O14791

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	188	0.66	0.85	23	empty
2	71	0.36	0.77	14	empty

Compared structures

7L6K · ApoL1 N-terminal domain · the same entry in another collection · chain A against A, TM-score 1.00
O14791 · AlphaFold monomer V2.0 prediction for apolipoprotein L1 (O14791) · a predicted model of the same protein · chain A against A, TM-score 0.68

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O14791
Elsewhere: RCSB PDB 7L6K · PDBe 7L6K · UniProt O14791

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