MolNFT v1 · #180438 · protein
Substrate-dependent divergence of leukotriene A4 hydrolase aminopeptidase activity
7KZE · Leukotriene a-4 hydrolase: “Substrate-dependent divergence of leukotriene A4 hydrolase aminopeptidase activity”. X-ray diffraction, 2 ligands (N0Y, ZN), 16 pockets (best druggability 0.87). MolNFT v1 #180438 on GenesisL1: 3D…
- PDB
- 7KZE
- Type
- protein
- Length
- 1,823 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leukotriene a-4 hydrolase
- EC
- 3.3.2.6, 3.4.11.4
- UniProt
- P09960
- Ligands
- N0Y, ZN
- Pockets
- 16 · best druggability 0.87
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Leukotriene a-4 hydrolase (EC 3.3.2.6, 3.4.11.4) | protein | 608 | 43% helix, 24% strand | P09960 |
| C | Leukotriene a-4 hydrolase (EC 3.3.2.6, 3.4.11.4) | protein | 607 | 42% helix, 23% strand | P09960 |
Ligands and binding sites
- N0Y · 1-benzyl-4-methoxybenzene · ligand · 2 copies · chains A, C
- ZN · Zinc ion · metal · 3 copies · chains A, B, C
- PGE · Triethylene glycol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
16 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1074 | 0.87 | 0.88 | 116 | PGE |
| 2 | 1013 | 0.86 | 0.87 | 94 | N0Y |
| 3 | 1038 | 0.86 | 0.86 | 95 | ZN, N0Y |
| 4 | 394 | 0.73 | 0.84 | 66 | empty |
| 5 | 344 | 0.62 | 0.78 | 41 | empty |
Interfaces
3 interfaces between chains.
- A–B · 651 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 302 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 30 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7KZE · Substrate-dependent divergence of leukotriene A4 hydrolase aminopeptidase activity · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09960
- Elsewhere: RCSB PDB 7KZE · PDBe 7KZE · UniProt P09960
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.