MolNFT v1 · #180419 · protein

Crystal structure of plasmodium falciparum dihydroorotate dehydrogenase bound with inhibitor DSM634 (3-methyl-N-(1-(5- methylisoxazol-3-YL)ETHYL)-4-(4-(TRIFLUOROMETHYL)BENZYL)-1H-pyrrole- 2-carboxamide)

7KYV: “Crystal structure of plasmodium falciparum dihydroorotate dehydrogenase bound with inhibitor DSM634…”. X-ray diffraction, 3 ligands (XBY, FMN, ORO). MolNFT v1 #180419 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7KYV
Type: protein
Length: 374 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q08210
Ligands: XBY, FMN, ORO

Structure

x-ray diffraction · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	374	—	Q08210

Ligands and binding sites

XBY · 3-methyl-N-[(1R)-1-(5-methyl-1,2-oxazol-3-yl)ethyl]-4-{[4-(trifluoromethyl)phenyl]methyl}-1H-pyrrole-2-carboxamide · ligand · chains A
FMN · Flavin mononucleotide · ligand · chains A
ORO · Orotic acid · ligand · chains A
GOL · Glycerol · additive · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7KYV · Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with… · the same entry in another collection · chain A against A, TM-score 1.00
Q08210 · AlphaFold monomer V2.0 prediction for dihydroorotate dehydrogenase (quinone)… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q08210
Elsewhere: RCSB PDB 7KYV · PDBe 7KYV · UniProt Q08210

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.