MolNFT v1 · #180409 · protein

Crystal structure of plasmodium falciparum dihydroorotate dehydrogenase bound with inhibitor DSM589 (ethyl 3-methyl-4-((4- (TRIFLUOROMETHYL)BENZO[D]OXAZOL-7-YL)METHYL)-1H-pyrrole-2- carboxylate)

7KYK: “Crystal structure of plasmodium falciparum dihydroorotate dehydrogenase bound with inhibitor DSM589 (ethyl…”. X-ray diffraction, 3 ligands (XAJ, FMN, ORO). MolNFT v1 #180409 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 7KYK
Type: protein
Length: 1,484 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q08210
Ligands: XAJ, FMN, ORO

Structure

x-ray diffraction · 4 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	376	—	Q08210
B	—	protein	370	—	Q08210
C	—	protein	369	—	Q08210
D	—	protein	369	—	Q08210

Ligands and binding sites

XAJ · ethyl 3-methyl-4-{[4-(trifluoromethyl)-1,3-benzoxazol-7-yl]methyl}-1H-pyrrole-2-carboxylate · ligand · 4 copies · chains A, B, C, D
FMN · Flavin mononucleotide · ligand · 4 copies · chains A, B, C, D
ORO · Orotic acid · ligand · 4 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7KYK · Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with… · the same entry in another collection · chain D against D, TM-score 1.00
Q08210 · AlphaFold monomer V2.0 prediction for dihydroorotate dehydrogenase (quinone)… · a predicted model of the same protein · chain C against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q08210
Elsewhere: RCSB PDB 7KYK · PDBe 7KYK · UniProt Q08210

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.