MolNFT v1 · #180389 · protein
Cryo-EM structure of human factor va at 4.4 ångström resolution
7KXY · Coagulation factor va: “Cryo-EM structure of human factor va at 4.4 ångström resolution”. Electron microscopy, 20 pockets (best druggability 0.88). MolNFT v1 #180389 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7KXY
- Type
- protein
- Length
- 1,181 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Coagulation factor va
- UniProt
- P12259
- Pockets
- 20 · best druggability 0.88
Structure
electron microscopy · 2 distinct chains · 2% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Coagulation factor va | protein | 588 | 2% helix, 12% strand | P12259 |
| B | Coagulation factor va | protein | 593 | 2% helix, 13% strand | P12259 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 680 | 0.88 | 0.92 | 92 | empty |
| 2 | 347 | 0.86 | 0.95 | 50 | empty |
| 3 | 151 | 0.80 | 0.96 | 26 | empty |
| 4 | 991 | 0.75 | 0.78 | 93 | empty |
| 5 | 69 | 0.74 | 0.98 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 3020 Ų buried · 31 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12259
- Elsewhere: RCSB PDB 7KXY · PDBe 7KXY · UniProt P12259
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