MolNFT v1 · #180268 · protein + DNA

Cryo-EM structure of rous sarcoma virus cleaved synaptic complex (csc) with HIV-1 integrase strand transfer inhibitor mk-2048. cluster identified by 3-dimensional variability analysis in cryosparc.

7KU7: “Cryo-EM structure of rous sarcoma virus cleaved synaptic complex (csc) with HIV-1 integrase strand transfer…”. Electron microscopy, 3 ligands (ZZX, MG, ZN). MolNFT v1 #180268 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 7KU7
Type: protein + DNA
Length: 1,875 residues
Chains: 12
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P03354
Ligands: ZZX, MG, ZN

Structure

electron microscopy · 8 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, E	—	protein	269	—	P03354
B	—	protein	213	—	P03354
C	—	protein	210	—	P03354
D	—	protein	212	—	P03354
F	—	protein	214	—	P03354
G, H	—	protein	210	—	P03354
I, K	—	dna	18	—	—
J, L	—	dna	16	—	—

Ligands and binding sites

ZZX · (6S)-2-(3-chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N, 6-dimethyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1', 2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide · ligand · 2 copies · chains A, I, J, E, K, L
MG · Magnesium ion · metal · 4 copies · chains A, E
ZN · Zinc ion · metal · 2 copies · chains A, E

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7KU7 · Cryo-EM structure of Rous sarcoma virus cleaved synaptic complex (CSC) with HIV-1… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03354
Elsewhere: RCSB PDB 7KU7 · PDBe 7KU7 · UniProt P03354

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