MolNFT v1 · #180206 · protein

Crystal structure of prototype foamy virus protease-reverse transcriptase (native)

7KSF · PROTEASE/REVERSE TRANSCRIPTASE/RIBONUCLEASE H: “Crystal structure of prototype foamy virus protease-reverse transcriptase (native)”. X-ray diffraction, 1 ligand (CA), 11 pockets (best druggability 0.83). MolNFT v1 #180206 on…

PDB: 7KSF
Type: protein
Length: 742 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: PROTEASE/REVERSE TRANSCRIPTASE/RIBONUCLEASE H
EC: 2.7.7.49, 2.7.7.7, 3.1.26.4
UniProt: A0A1Q1N9V8
Ligands: CA
Pockets: 11 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	PROTEASE/REVERSE TRANSCRIPTASE/RIBONUCLEASE H (EC 2.7.7.49, 2.7.7.7, 3.1.26.4)	protein	742	33% helix, 24% strand	A0A1Q1N9V8

Ligands and binding sites

CA · Calcium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

11 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1180	0.83	0.84	101	empty
2	82	0.74	0.97	24	empty
3	188	0.66	0.85	38	empty
4	275	0.65	0.82	42	empty
5	265	0.62	0.80	40	empty

Compared structures

7KSF · Crystal structure of Prototype Foamy Virus Protease-Reverse Transcriptase (native) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A1Q1N9V8
Elsewhere: RCSB PDB 7KSF · PDBe 7KSF · UniProt A0A1Q1N9V8

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