MolNFT v1 · #180205 · protein
Crystal structure of prototype foamy virus protease-reverse transcriptase csh mutant (selenomethionine-labeled)
7KSE · Peptidase A9/REVERSE TRANSCRIPTASE/RNASE H: “Crystal structure of prototype foamy virus protease-reverse transcriptase csh mutant…”. X-ray diffraction, 1 ligand (CA), 11 pockets (best druggability 0.85). MolNFT v1 #180205 on…
- PDB
- 7KSE
- Type
- protein
- Length
- 742 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peptidase A9/REVERSE TRANSCRIPTASE/RNASE H
- EC
- 2.7.7.49, 2.7.7.7, 3.1.26.4
- UniProt
- A0A1Q1N9V8
- Ligands
- CA
- Pockets
- 11 · best druggability 0.85
Structure
x-ray diffraction · 1 distinct chain · 29% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peptidase A9/REVERSE TRANSCRIPTASE/RNASE H (EC 2.7.7.49, 2.7.7.7, 3.1.26.4) | protein | 742 | 29% helix, 25% strand | A0A1Q1N9V8 |
Ligands and binding sites
- CA · Calcium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1124 | 0.85 | 0.86 | 99 | empty |
| 2 | 80 | 0.73 | 0.96 | 17 | empty |
| 3 | 533 | 0.68 | 0.78 | 63 | empty |
| 4 | 335 | 0.63 | 0.79 | 51 | empty |
| 5 | 113 | 0.57 | 0.84 | 26 | empty |
Modifications
Observed in the structure: 13 modified (engineered).
Compared structures
- 7KSE · Crystal structure of Prototype Foamy Virus Protease-Reverse Transcriptase CSH mutant… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A1Q1N9V8
- Elsewhere: RCSB PDB 7KSE · PDBe 7KSE · UniProt A0A1Q1N9V8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.