MolNFT v1 · #180197 · protein
GLUK2/K5 with 6-cyano-7-nitroquinoxaline-2,3-dione (cnqx)
7KS0 · Glutamate receptor ionotropic, kainate 5,GREEN fluorescent…: “GLUK2/K5 with 6-cyano-7-nitroquinoxaline-2,3-dione (cnqx)”. Electron microscopy, 20 pockets (best druggability 0.83). MolNFT v1 #180197 on GenesisL1: 3D structure…
- PDB
- 7KS0
- Type
- protein
- Length
- 2,956 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor ionotropic, kainate 5,GREEN fluorescent protein chimera; Glutamate…
- UniProt
- Q63273, P42260
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 2 distinct chains · 39% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Glutamate receptor ionotropic, kainate 5,GREEN fluorescent protein chimera | protein | 741 | 39% helix, 15% strand | Q63273 |
| B, D | Glutamate receptor ionotropic, kainate 2 | protein | 737 | 39% helix, 17% strand | P42260 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 820 | 0.83 | 0.85 | 120 | empty |
| 2 | 698 | 0.79 | 0.84 | 101 | empty |
| 3 | 974 | 0.78 | 0.80 | 87 | empty |
| 4 | 824 | 0.76 | 0.80 | 89 | empty |
| 5 | 412 | 0.74 | 0.85 | 88 | empty |
Interfaces
6 interfaces between chains.
- C–D · 2638 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 2512 Ų buried · 13 hydrogen bonds · protein-protein
- A–D · 1041 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 1028 Ų buried · 4 hydrogen bonds · protein-protein
- B–D · 583 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 7KS0 · GluK2/K5 with 6-Cyano-7-nitroquinoxaline-2,3-dione (CNQX) · the same entry in another collection · chain A against A, TM-score 1.00
- Q63273 · AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, kainate 5 (Q63273) · a predicted model of the same protein · chain C against A, TM-score 0.82
- P42260 · AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, kainate 2 (P42260) · a predicted model of the same protein · chain B against A, TM-score 0.54
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q63273
- Every structure of UniProt P42260
- Elsewhere: RCSB PDB 7KS0 · PDBe 7KS0 · UniProt Q63273 · UniProt P42260
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