MolNFT v1 · #180097 · protein
Crystal structure of human claudin-4 in complex with clostridium perfringens enterotoxin C-terminal domain
7KP4: “Crystal structure of human claudin-4 in complex with clostridium perfringens enterotoxin C-terminal domain”. X-ray diffraction, 2 pockets (best druggability 0.57). MolNFT v1 #180097 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7KP4
- Type
- protein
- Length
- 316 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Claudin-4; Heat-labile enterotoxin B chain
- UniProt
- O14493, P01558
- Pockets
- 2 · best druggability 0.57
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Claudin-4 | protein | 182 | 53% helix, 11% strand | O14493 |
| B | Heat-labile enterotoxin B chain | protein | 134 | 5% helix, 48% strand | P01558 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 163 | 0.57 | 0.82 | 27 | empty |
| 2 | 94 | 0.37 | 0.76 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1388 Ų buried · 20 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7KP4 · Crystal structure of human claudin-4 in complex with Clostridium perfringens enterotoxin… · the same entry in another collection · chain A against A, TM-score 1.00
- O14493 · AlphaFold monomer V2.0 prediction for claudin-4 (O14493) · a predicted model of the same protein · chain A against A, TM-score 0.95
- P01558 · AlphaFold monomer V2.0 prediction for heat-labile enterotoxin B chain (P01558) · a predicted model of the same protein · chain B against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14493
- Every structure of UniProt P01558
- Elsewhere: RCSB PDB 7KP4 · PDBe 7KP4 · UniProt O14493 · UniProt P01558
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