UniProt O14493
Claudin-4 (O14493)
Claudin-4 (UniProt O14493): 11 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 15 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O14493
- Protein
- Claudin-4
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 15 · 6 records with a druggable one
Structures
12 records of O14493 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5B2G | Crystal structure of human claudin-4 in complex with C-terminal fragment of clostridium perfringens… | x-ray diffraction | A, C, E, G | — | — |
| 7KP4 | Crystal structure of human claudin-4 in complex with Clostridium perfringens enterotoxin C-terminal… | x-ray diffraction | A | — | 2 (best 0.57) |
| 7KP4 | Crystal structure of human claudin-4 in complex with clostridium perfringens enterotoxin C-terminal… | x-ray diffraction | A | — | — |
| 7TDM | CryoEM Structure of sFab COP-2 Complex with human claudin-4 and Clostridium perfringens enterotoxin… | electron microscopy | A | — | — |
| 7TDM | Cryoem structure of sfab cop-2 complex with human claudin-4 and clostridium perfringens enterotoxin… | electron microscopy | A | — | — |
| 7TDN | CryoEM Structure of sFab COP-3 Complex with human claudin-4 and Clostridium perfringens enterotoxin… | electron microscopy | A | — | 3 (best 0.82) |
| 7TDN | Cryoem structure of sfab cop-3 complex with human claudin-4 and clostridium perfringens enterotoxin… | electron microscopy | A | — | — |
| 8U4V | Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin C-terminal… | electron microscopy | A | AV0 | 3 (best 0.62) |
| 8U5B | Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin C-terminal… | electron microscopy | A | AV0 | 3 (best 0.67) |
| 9CMH | Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin | electron microscopy | A | — | 1 (best 0.74) |
| 9CMI | Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin, sFab COP-1… | electron microscopy | A | AV0 | 3 (best 0.65) |
| O14493 | AlphaFold monomer V2.0 prediction for claudin-4 (O14493) | predicted | A | — | — |
Ligands
- AV0 · 2-decyl-2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}dodecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside · in 3 records
Experiment against prediction
- 8U4V chain A against the predicted model O14493: TM-score 0.96, RMSD 1.04 Å
- 9CMI chain A against the predicted model O14493: TM-score 0.96, RMSD 1.07 Å
- 8U5B chain A against the predicted model O14493: TM-score 0.96, RMSD 1.12 Å
- 7KP4 chain A against the predicted model O14493: TM-score 0.95, RMSD 1.24 Å
- 7KP4 chain A against the predicted model O14493: TM-score 0.95, RMSD 1.24 Å
- 9CMH chain A against the predicted model O14493: TM-score 0.89, RMSD 1.81 Å
- 7TDN chain A against the predicted model O14493: TM-score 0.88, RMSD 2.03 Å
- 7TDN chain A against the predicted model O14493: TM-score 0.88, RMSD 2.03 Å
- 7TDM chain A against the predicted model O14493: TM-score 0.87, RMSD 2.26 Å
- 7TDM chain A against the predicted model O14493: TM-score 0.87, RMSD 2.26 Å
Elsewhere
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