MolNFT v1 · #180074 · protein
Cryo-EM structure of heavy chain mouse apoferritin
7KOD · Ferritin heavy chain: “Cryo-EM structure of heavy chain mouse apoferritin”. Electron microscopy, 20 pockets (best druggability 0.75). MolNFT v1 #180074 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7KOD
- Type
- protein
- Length
- 4,128 residues
- Chains
- 24
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ferritin heavy chain
- EC
- 1.16.3.1
- UniProt
- P09528
- Pockets
- 20 · best druggability 0.75
Structure
electron microscopy · 1 distinct chain · 73% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X | Ferritin heavy chain (EC 1.16.3.1) | protein | 172 | 73% helix, 1% strand | P09528 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 75 | 0.75 | 0.97 | 16 | empty |
| 2 | 69 | 0.74 | 0.98 | 15 | empty |
| 3 | 301 | 0.67 | 0.83 | 40 | empty |
| 4 | 307 | 0.66 | 0.82 | 42 | empty |
| 5 | 312 | 0.66 | 0.82 | 41 | empty |
Interfaces
72 interfaces between chains.
- C–J · 1564 Ų buried · 29 hydrogen bonds · protein-protein
- L–S · 1557 Ų buried · 29 hydrogen bonds · protein-protein
- P–U · 1549 Ų buried · 29 hydrogen bonds · protein-protein
- O–V · 1547 Ų buried · 29 hydrogen bonds · protein-protein
- H–K · 1546 Ų buried · 29 hydrogen bonds · protein-protein
Compared structures
- 7KOD · Cryo-EM structure of heavy chain mouse apoferritin · the same entry in another collection · chain I against I, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09528
- Elsewhere: RCSB PDB 7KOD · PDBe 7KOD · UniProt P09528
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