MolNFT v1 · #179910 · protein
Crystal structure of human mdmx in complex with D-peptide inhibitor (dpmi-omega)
7KJN · Protein MDM4: “Crystal structure of human mdmx in complex with D-peptide inhibitor (dpmi-omega)”. X-ray diffraction. MolNFT v1 #179910 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7KJN
- Type
- protein
- Length
- 109 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein MDM4; D-pmi-omega
- UniProt
- O15151
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein MDM4 | protein | 85 | 44% helix, 20% strand | O15151 |
| B, C | D-pmi-omega | protein | 12 | 33% helix, 0% strand | — |
Interfaces
3 interfaces between chains.
- A–C · 567 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 488 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 140 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 22 d-amino, 2 modified (D-amino acid, nonstandard).
Compared structures
- 7KJN · Crystal structure of human mdmx in complex with D-peptide inhibitor (dpmi-omega) · the same entry in another collection · chain A against A, TM-score 1.00
- O15151 · AlphaFold monomer V2.0 prediction for protein MDM4 (O15151) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O15151
- Elsewhere: RCSB PDB 7KJN · PDBe 7KJN · UniProt O15151
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