MolNFT v1 · #179899 · protein

Crystal structure of the EPHA2 S897E/S901E mutant intracellular kd-SAM domains

7KJB · Ephrin type-a receptor 2: “Crystal structure of the EPHA2 S897E/S901E mutant intracellular kd-SAM domains”. X-ray diffraction, 1 ligand (CS), 3 pockets (best druggability 0.70). MolNFT v1 #179899 on GenesisL1: 3D structure, binding…

PDB: 7KJB
Type: protein
Length: 361 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ephrin type-a receptor 2
EC: 2.7.10.1
UniProt: P29317
Ligands: CS
Pockets: 3 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ephrin type-a receptor 2 (EC 2.7.10.1)	protein	361	44% helix, 14% strand	P29317

Ligands and binding sites

CS · Cesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	473	0.70	0.81	56	empty
2	113	0.41	0.76	20	empty
3	53	0.34	0.78	11	empty

Compared structures

7KJB · Crystal structure of the EphA2 S897E/S901E mutant intracellular KD-SAM domains · the same entry in another collection · chain A against A, TM-score 1.00
P29317 · AlphaFold monomer V2.0 prediction for ephrin type-a receptor 2 (P29317) · a predicted model of the same protein · chain A against A, TM-score 0.78

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P29317
Elsewhere: RCSB PDB 7KJB · PDBe 7KJB · UniProt P29317

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