MolNFT v1 · #179887 · protein
Reduced human peroxiredoxin 2
7KIZ · Peroxiredoxin-2: “Reduced human peroxiredoxin 2”. X-ray diffraction, 20 pockets (best druggability 0.73). MolNFT v1 #179887 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7KIZ
- Type
- protein
- Length
- 1,970 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peroxiredoxin-2
- EC
- 1.11.1.24
- UniProt
- P32119
- Pockets
- 20 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 30% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J | Peroxiredoxin-2 (EC 1.11.1.24) | protein | 197 | 30% helix, 26% strand | P32119 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 61 | 0.73 | 0.99 | 20 | empty |
| 2 | 56 | 0.72 | 0.99 | 22 | empty |
| 3 | 58 | 0.72 | 0.98 | 19 | empty |
| 4 | 50 | 0.71 | 0.99 | 20 | empty |
| 5 | 210 | 0.64 | 0.83 | 35 | empty |
Interfaces
20 interfaces between chains.
- G–H · 2159 Ų buried · 29 hydrogen bonds · protein-protein
- E–F · 2129 Ų buried · 30 hydrogen bonds · protein-protein
- I–J · 2112 Ų buried · 33 hydrogen bonds · protein-protein
- C–D · 2099 Ų buried · 30 hydrogen bonds · protein-protein
- A–B · 2085 Ų buried · 30 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32119
- Elsewhere: RCSB PDB 7KIZ · PDBe 7KIZ · UniProt P32119
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