MolNFT v1 · #179789 · protein
Recombinant beta-2-glycoprotein I antibody recognition loop mutant
7KG4 · Beta-2-glycoprotein 1: “Recombinant beta-2-glycoprotein I antibody recognition loop mutant”. X-ray diffraction, 3 ligands (NAG, FUC, MAN), 2 pockets (best druggability 0.54). MolNFT v1 #179789 on GenesisL1: 3D structure, binding…
- PDB
- 7KG4
- Type
- protein
- Length
- 652 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-2-glycoprotein 1
- UniProt
- P02749
- Ligands
- NAG, FUC, MAN
- Pockets
- 2 · best druggability 0.54
Structure
x-ray diffraction · 1 distinct chain · 1% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Beta-2-glycoprotein 1 | protein | 326 | 1% helix, 40% strand | P02749 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 11 copies · chains A, B
- FUC · alpha-L-fucopyranose · sugar · 3 copies · chains A
- MAN · alpha-D-mannopyranose · sugar · 2 copies
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 160 | 0.54 | 0.80 | 23 | empty |
| 2 | 100 | 0.48 | 0.81 | 22 | empty |
Modifications
Observed in the structure: 22 disulfide, 7 glycan (disulfide, N-glycosylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02749
- Elsewhere: RCSB PDB 7KG4 · PDBe 7KG4 · UniProt P02749
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