MolNFT v1 · #179717 · protein

Crystal structure of the bromodomain (bd) of human bromodomain and phd finger-containing transcription factor (bptf) bound to tp-238

7KDZ · Nucleosome-remodeling factor subunit bptf: “Crystal structure of the bromodomain (bd) of human bromodomain and phd finger-containing transcription factor…”. X-ray diffraction, 1 ligand (WCS), 1 pocket (best druggability 0.58).…

PDB: 7KDZ
Type: protein
Length: 105 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nucleosome-remodeling factor subunit bptf
UniProt: Q12830
Ligands: WCS
Pockets: 1 · best druggability 0.58

Structure

x-ray diffraction · 1 distinct chain · 70% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nucleosome-remodeling factor subunit bptf	protein	105	70% helix, 0% strand	Q12830

Ligands and binding sites

WCS · 6-{4-[3-(dimethylamino)propoxy]phenyl}-2-(methylsulfonyl)-N-[3-(1H-pyrazol-1-yl) propyl]pyrimidin-4-amine · ligand · chains A
EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	114	0.58	0.85	21	WCS

Compared structures

7KDZ · Crystal structure of the bromodomain (BD) of human Bromodomain and PHD finger-containing… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q12830
Elsewhere: RCSB PDB 7KDZ · PDBe 7KDZ · UniProt Q12830

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