UniProt Q12830
Nucleosome-remodeling factor subunit BPTF (Q12830)
Nucleosome-remodeling factor subunit BPTF (UniProt Q12830): 63 experimental structures on GenesisL1, 28 ligands bound, 20 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q12830
- Protein
- Nucleosome-remodeling factor subunit BPTF
- Experimental structures
- 63
- Predicted models
- 0
- Ligands
- 28
- Pockets
- 20 · 15 records with a druggable one
Structures
63 records of Q12830 in the MolNFT archive: 63 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2RI7 | Crystal structure of PHD finger-linker-bromodomain Y17E mutant from human BPTF in the H3(1-9)K4ME2… | x-ray diffraction | A | — | — |
| 2RI7 | Crystal structure of phd finger-linker-bromodomain Y17E mutant from human bptf in the H3(1-9)K4ME2… | x-ray diffraction | A | — | — |
| 3QZS | Crystal Structure of BPTF bromo in complex with histone H4K16ac - Form I | x-ray diffraction | A, B | — | — |
| 3QZS | Crystal structure of bptf bromo in complex with histone H4K16AC - form I | x-ray diffraction | A, B | — | — |
| 3QZT | Crystal Structure of BPTF bromo in complex with histone H4K16ac - Form II | x-ray diffraction | A | — | — |
| 3QZT | Crystal structure of bptf bromo in complex with histone H4K16AC - form II | x-ray diffraction | A | — | — |
| 3QZV | Crystal Structure of BPTF PHD-linker-bromo in complex with histone H4K12ac peptide | x-ray diffraction | A | — | — |
| 3QZV | Crystal structure of bptf phd-linker-bromo in complex with histone H4K12AC peptide | x-ray diffraction | A | — | — |
| 3UV2 | Crystal structure of the bromodomain of human nucleosome-remodeling factor subunit BPTF | x-ray diffraction | A | — | — |
| 3UV2 | Crystal structure of the bromodomain of human nucleosome-remodeling factor subunit bptf | x-ray diffraction | A | — | — |
| 5H6Y | The BPTF Bromodomain Recognising H4K12Cr peptide | x-ray diffraction | A | — | — |
| 5H6Y | The bptf bromodomain recognising H4K12CR peptide | x-ray diffraction | A | — | — |
| 5R4G | PanDDA analysis group deposition -- CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN… | x-ray diffraction | A | RU4 | 1 (best 0.52) |
| 5R4G | Pandda analysis group deposition -- crystal structure of the bromodomain of human… | x-ray diffraction | A | RU4 | — |
| 5R4H | PanDDA analysis group deposition -- CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN… | x-ray diffraction | A | HWH | — |
| 5R4H | Pandda analysis group deposition -- crystal structure of the bromodomain of human… | x-ray diffraction | A | HWH | — |
| 5R4I | PanDDA analysis group deposition -- CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN… | x-ray diffraction | A | RUV | — |
| 5R4I | Pandda analysis group deposition -- crystal structure of the bromodomain of human… | x-ray diffraction | A | RUV | — |
| 5R4J | PanDDA analysis group deposition -- CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN… | x-ray diffraction | A | RUY | 1 (best 0.51) |
| 5R4J | Pandda analysis group deposition -- crystal structure of the bromodomain of human… | x-ray diffraction | A | RUY | — |
| 5R4K | PanDDA analysis group deposition -- CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN… | x-ray diffraction | A | K0V | 1 (best 0.52) |
| 5R4K | Pandda analysis group deposition -- crystal structure of the bromodomain of human… | x-ray diffraction | A | K0V | — |
| 5R4L | PanDDA analysis group deposition -- CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN… | x-ray diffraction | A | RV4 | — |
| 5R4L | Pandda analysis group deposition -- crystal structure of the bromodomain of human… | x-ray diffraction | A | RV4 | — |
| 5R4M | PanDDA analysis group deposition -- CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN… | x-ray diffraction | A | M25 | 1 (best 0.51) |
| 5R4M | Pandda analysis group deposition -- crystal structure of the bromodomain of human… | x-ray diffraction | A | M25 | — |
| 5R4N | PanDDA analysis group deposition -- CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN… | x-ray diffraction | A | K3D | 1 (best 0.52) |
| 5R4N | Pandda analysis group deposition -- crystal structure of the bromodomain of human… | x-ray diffraction | A | K3D | — |
| 5R4O | PanDDA analysis group deposition of ground-state model of BROMODOMAIN OF HUMAN… | x-ray diffraction | A | — | 1 (best 0.55) |
| 5R4O | Pandda analysis group deposition of ground-state model of bromodomain of human… | x-ray diffraction | A | — | — |
| 6AZE | Crystal Structure of the BPTF PHD-bromodomain module bound to H3KC4me3 methyl lysine analog | x-ray diffraction | A | ZN | — |
| 6AZE | Crystal structure of the bptf phd-bromodomain module bound to H3KC4ME3 methyl lysine analog | x-ray diffraction | A | ZN | — |
| 7DMY | The crystal structure of CPD7 in complex with bptf bromodomain | x-ray diffraction | A | HAF | — |
| 7DN4 | The crystal structure of CPD8 in complex with bptf bromodomain | x-ray diffraction | A, B, C, D, E, F | JC3 | — |
| 7JT4 | Crystal Structure of BPTF bromodomain labelled with 5-fluoro-tryptophan | x-ray diffraction | A | — | — |
| 7JT4 | Crystal structure of bptf bromodomain labelled with 5-fluoro- tryptophan | x-ray diffraction | A | — | — |
| 7K6R | Crystal structure of the bromodomain (BD) of human Bromodomain and PHD finger-containing… | x-ray diffraction | A | 9ST | 1 (best 0.52) |
| 7K6R | Crystal structure of the bromodomain (bd) of human bromodomain and phd finger-containing… | x-ray diffraction | A | 9ST | — |
| 7K6S | Crystal structure of the bromodomain (BD) of human Bromodomain and PHD finger-containing… | x-ray diffraction | A | VYM, CL | 1 (best 0.52) |
| 7K6S | Crystal structure of the bromodomain (bd) of human bromodomain and phd finger-containing… | x-ray diffraction | A | VYM, CL | — |
| 7KDW | Crystal structure of the bromodomain (BD) of human Bromodomain and PHD finger-containing… | x-ray diffraction | A, B | WCV | — |
| 7KDW | Crystal structure of the bromodomain (bd) of human bromodomain and phd finger-containing… | x-ray diffraction | A, B | WCV | — |
| 7KDZ | Crystal structure of the bromodomain (bd) of human bromodomain and phd finger-containing… | x-ray diffraction | A | WCS | — |
| 7LP0 | Crystal structure of BPTF bromodomain in complex with inhibitor Pdy-3-077 | x-ray diffraction | A, B | P2L | — |
| 7LP0 | Crystal structure of bptf bromodomain in complex with inhibitor pdy-3- 077 | x-ray diffraction | A, B | P2L | — |
| 7LPK | Crystal structure of BPTF bromodomain in complex with inhibitor HZ-03-112 | x-ray diffraction | A, B | Y9P | 2 (best 0.56) |
| 7LPK | Crystal structure of bptf bromodomain in complex with inhibitor hz-03- 112 | x-ray diffraction | A, B | Y9P | — |
| 7LRK | Crystal structure of BPTF bromodomain in complex with inhibitor Pdy-3-093 | x-ray diffraction | A, B | YC4 | 2 (best 0.58) |
| 7LRK | Crystal structure of bptf bromodomain in complex with inhibitor pdy-3- 093 | x-ray diffraction | A, B | YC4 | — |
| 7LRO | Crystal structure of BPTF bromodomain in complex with inhibitor HZ-01-105 | x-ray diffraction | A, B | YBV | 3 (best 0.57) |
| 7LRO | Crystal structure of bptf bromodomain in complex with inhibitor hz-01- 105 | x-ray diffraction | A, B | YBV | — |
| 7M2E | Crystal structure of BPTF bromodomain in complex with CB02-092 | x-ray diffraction | A | YOV | 1 (best 0.50) |
| 7M2E | Crystal structure of bptf bromodomain in complex with CB02-092 | x-ray diffraction | A | YOV | — |
| 7RWN | Crystal Structure of BPTF bromodomain in complex with… | x-ray diffraction | A | 7WE | 1 (best 0.49) |
| 7RWN | Crystal structure of bptf bromodomain in complex with 4-chloro-5-{4… | x-ray diffraction | A | 7WE | — |
| 7RWO | Crystal structure of bptf bromodomain with a selective inhibitor | x-ray diffraction | A | 7WN | — |
| 7RWP | Crystal Structure of BPTF bromodomain in complex with… | x-ray diffraction | A | 7WZ, CA | 1 (best 0.50) |
| 7RWP | Crystal structure of bptf bromodomain in complex with 5-[4… | x-ray diffraction | A | 7WZ, CA | — |
| 7RWQ | Crystal Structure of BPTF bromodomain in complex with… | x-ray diffraction | A | 7XE, CA | 1 (best 0.51) |
| 7RWQ | Crystal structure of bptf bromodomain in complex with 4-chloro-2… | x-ray diffraction | A | 7XE, CA | — |
3 records more on the page itself.
Ligands
- CA · Calcium ion · in 4 records
- 7WE · 4-chloro-5-{4-[(dimethylamino)methyl]anilino}-2-methylpyridazin-3(2H)-one · in 2 records
- 7WZ · 5-[4-(aminomethyl)anilino]-4-chloro-2-methylpyridazin-3(2H)-one · in 2 records
- 7XE · 4-chloro-2-methyl-5-[(1,2,3,4-tetrahydroisoquinolin-6-yl)amino]pyridazin-3(2H)-one · in 2 records
- 9ST · 4-bromo-2-methyl-5-[[(3~{R},5~{R})-1-methyl-5-phenyl-piperidin-3-yl]amino]pyridazin-3-one · in 2 records
- CL · Chloride ion · in 2 records
- HWH · ~{N}-[2-(5-fluoranyl-1~{H}-indol-3-yl)ethyl]ethanamide · in 2 records
- K0V · methyl 1-(tert-butylcarbamoyl)piperidine-4-carboxylate · in 2 records
- K3D · 4-acetyl-N-ethylpiperazine-1-carboxamide · in 2 records
- M1I · 5-[3-methoxy-4-[1-(4-methylpiperazin-1-yl) cyclopropyl]phenyl]-1,3,4-trimethyl-pyridin-2-one · in 2 records
- M25 · N-{2-[4-(aminosulfonyl)phenyl]ethyl}acetamide · in 2 records
- P2L · 4-chlorol-2-methyl-5-[[(3~{R})-1-methylpiperidin-3-yl]amino]pyridazin-3-one · in 2 records
- RU4 · 4-(1,2,3-thiadiazol-4-yl)phenyl ethylcarbamate · in 2 records
- RUV · 4-(acetylamino)-N-(4H-1,2,4-triazol-4-yl)benzamide · in 2 records
- RUY · 4-(piperidin-1-yl)-1,2,5-oxadiazol-3-amine · in 2 records
- RV4 · N-{4-[(morpholin-4-yl)methyl]phenyl}acetamide · in 2 records
- VYM · (7-amino-3,4-dihydroquinolin-1(2H)-yl)(cyclopropyl) methanone · in 2 records
- WCV · cyclopropyl[7-({2-[(prop-2-yn-1-yl)amino]pyrimidin-4-yl}amino)-3,4-dihydroquinolin-1(2H)-yl]methanone · in 2 records
- Y9P · 4-chloranyl-2-methyl-5-[[(3~{R})-pyrrolidin-3-yl]amino]pyridazin-3-one · in 2 records
- YBV · 5-(azetidin-3-ylamino)-4-chloranyl-2-methyl-pyridazin-3-one · in 2 records
- YC4 · 4-chloranyl-2-methyl-5-[[(3~{S})-pyrrolidin-3-yl]amino]pyridazin-3-one · in 2 records
- YOV · 4-chloro-5-{4-[2-(dimethylamino)ethyl]anilino}-2-methylpyridazin-3(2H)-one · in 2 records
- ZN · Zinc ion · in 2 records
- 7WN · 4-chloro-2-methyl-5-[(1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyridazin-3(2H)-one · in 1 record
- HAF · Tert-butyl 3-methyl-2-[[(3R,5R)-1-methyl-5-phenyl-piperidin-3-yl]amino]-4-oxidanylidene-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylate · in 1 record
- JC3 · 3-methyl-2-[[(3R,5R)-1-methyl-5-phenyl-piperidin-3-yl]amino]-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-one · in 1 record
- WCS · 6-{4-[3-(dimethylamino)propoxy]phenyl}-2-(methylsulfonyl)-N-[3-(1H-pyrazol-1-yl) propyl]pyrimidin-4-amine · in 1 record
- XHK · 6-[4-(2-aminoethyl)anilino]-5-chloro-3-methylpyrimidin-4(3H)-one · in 1 record
Elsewhere
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