MolNFT v1 · #179567 · protein

Aldolase, rabbit muscle (no beam-tilt refinement)

7K9L · Fructose-bisphosphate aldolase a: “Aldolase, rabbit muscle (no beam-tilt refinement)”. Electron microscopy, 14 pockets (best druggability 0.89). MolNFT v1 #179567 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7K9L
Type: protein
Length: 1,372 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fructose-bisphosphate aldolase a
EC: 4.1.2.13
UniProt: P00883
Pockets: 14 · best druggability 0.89

Structure

electron microscopy · 1 distinct chain · 48% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, A, C, D	Fructose-bisphosphate aldolase a (EC 4.1.2.13)	protein	343	48% helix, 16% strand	P00883

Pockets

14 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1091	0.89	0.90	144	empty
2	306	0.71	0.84	42	empty
3	105	0.64	0.89	20	empty
4	337	0.61	0.78	32	empty
5	337	0.60	0.78	34	empty

Interfaces

6 interfaces between chains.

A–C · 1484 Å² buried · 19 hydrogen bonds · protein-protein
B–D · 1479 Å² buried · 19 hydrogen bonds · protein-protein
B–A · 1082 Å² buried · 5 hydrogen bonds · protein-protein
C–D · 1058 Å² buried · 4 hydrogen bonds · protein-protein
B–C · 21 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

7K9L · Aldolase, rabbit muscle (no beam-tilt refinement) · the same entry in another collection · chain D against D, TM-score 1.00
P00883 · AlphaFold monomer V2.0 prediction for fructose-bisphosphate aldolase a (P00883) · a predicted model of the same protein · chain C against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00883
Elsewhere: RCSB PDB 7K9L · PDBe 7K9L · UniProt P00883

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