MolNFT v1 · #179478 · protein

Crystal structure of the bromodomain (bd) of human bromodomain and phd finger-containing transcription factor (bptf) bound to GSK4027

7K6R · Nucleosome-remodeling factor subunit bptf: “Crystal structure of the bromodomain (bd) of human bromodomain and phd finger-containing transcription factor…”. X-ray diffraction, 1 ligand (9ST), 1 pocket (best druggability 0.52).…

PDB: 7K6R
Type: protein
Length: 122 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nucleosome-remodeling factor subunit bptf
UniProt: Q12830
Ligands: 9ST
Pockets: 1 · best druggability 0.52

Structure

x-ray diffraction · 1 distinct chain · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nucleosome-remodeling factor subunit bptf	protein	122	72% helix, 0% strand	Q12830

Ligands and binding sites

9ST · 4-bromo-2-methyl-5-[[(3~{R},5~{R})-1-methyl-5-phenyl-piperidin-3-yl]amino]pyridazin-3-one · ligand · chains A
EDO · 1,2-ethanediol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	73	0.52	0.85	19	9ST

Compared structures

7K6R · Crystal structure of the bromodomain (BD) of human Bromodomain and PHD finger-containing… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q12830
Elsewhere: RCSB PDB 7K6R · PDBe 7K6R · UniProt Q12830

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