MolNFT v1 · #179384 · protein
Apoferritin structure at 1.36 ångström resolution determined from a 300 kv titan krios G3I electron microscope with FALCON4 detector
7K3W · Ferritin heavy chain: “Apoferritin structure at 1.36 ångström resolution determined from a 300 kv titan krios G3I electron…”. Electron microscopy, 2 ligands (ZN, NA), 20 pockets (best druggability 0.66). MolNFT v1 #179384 on…
- PDB
- 7K3W
- Type
- protein
- Length
- 4,128 residues
- Chains
- 24
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ferritin heavy chain
- EC
- 1.16.3.1
- UniProt
- P02794
- Ligands
- ZN, NA
- Pockets
- 20 · best druggability 0.66
Structure
electron microscopy · 1 distinct chain · 73% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X | Ferritin heavy chain (EC 1.16.3.1) | protein | 172 | 73% helix, 1% strand | P02794 |
Ligands and binding sites
- ZN · Zinc ion · metal · 270 copies · chains A, E, I, M, S, F, T, B, L, R, V, P, C, G, K, O, U, D, J, X, Q, H, N, W
- NA · Sodium ion · metal · 112 copies · chains A, F, S, T, B, P, M, C, U, V, D, G, E, J, Q, X, H, K, I, N, R, W, L, O
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 307 | 0.66 | 0.81 | 38 | ZN |
| 2 | 312 | 0.66 | 0.81 | 39 | ZN |
| 3 | 320 | 0.65 | 0.81 | 38 | ZN |
| 4 | 303 | 0.65 | 0.81 | 41 | ZN |
| 5 | 316 | 0.65 | 0.81 | 38 | ZN |
Interfaces
72 interfaces between chains.
- M–R · 1556 Ų buried · 32 hydrogen bonds · protein-protein
- O–V · 1556 Ų buried · 32 hydrogen bonds · protein-protein
- B–P · 1551 Ų buried · 32 hydrogen bonds · protein-protein
- L–N · 1551 Ų buried · 32 hydrogen bonds · protein-protein
- E–T · 1549 Ų buried · 32 hydrogen bonds · protein-protein
Compared structures
- 7K3W · Apoferritin structure at 1.36 angstrom resolution determined from a 300 kV Titan Krios… · the same entry in another collection · chain G against G, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02794
- Elsewhere: RCSB PDB 7K3W · PDBe 7K3W · UniProt P02794
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