MolNFT v1 · #179380 · protein
Solution NMR structure of the coiled-coil BRCA1-PALB2 heterodimer
7K3S · Breast cancer type 1 susceptibility protein homolog: “Solution NMR structure of the coiled-coil BRCA1-PALB2 heterodimer”. Solution nmr, 2 pockets (best druggability 0.32). MolNFT v1 #179380 on GenesisL1: 3D structure, binding sites…
- PDB
- 7K3S
- Type
- protein
- Length
- 128 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Breast cancer type 1 susceptibility protein homolog; Partner and localizer of BRCA2
- EC
- 2.3.2.27
- UniProt
- P48754, Q3U0P1
- Pockets
- 2 · best druggability 0.32
Structure
solution nmr · 2 distinct chains · 48% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Breast cancer type 1 susceptibility protein homolog (EC 2.3.2.27) | protein | 60 | 47% helix, 0% strand | P48754 |
| B | Partner and localizer of BRCA2 | protein | 68 | 49% helix, 0% strand | Q3U0P1 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 67 | 0.32 | 0.75 | 14 | empty |
| 2 | 66 | 0.32 | 0.75 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1458 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 7K3S · Solution NMR Structure of the Coiled-coil BRCA1-PALB2 Heterodimer · the same entry in another collection · chain A against A, TM-score 1.00
- P48754 · AlphaFold monomer V2.0 prediction for breast cancer type 1 susceptibility protein homolog… · a predicted model of the same protein · chain A against A, TM-score 0.50
- Q3U0P1 · AlphaFold monomer V2.0 prediction for partner and localizer of BRCA2 (Q3U0P1) · a predicted model of the same protein · chain B against A, TM-score 0.49
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P48754
- Every structure of UniProt Q3U0P1
- Elsewhere: RCSB PDB 7K3S · PDBe 7K3S · UniProt P48754 · UniProt Q3U0P1
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