MolNFT v1 · #179249 · protein

Low resolution crystal structure of zaire ebola virus VP40 in space group P6422

7JZT · Matrix protein VP40: “Low resolution crystal structure of zaire ebola virus VP40 in space group P6422”. X-ray diffraction, 14 pockets (best druggability 0.80). MolNFT v1 #179249 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 7JZT
Type: protein
Length: 915 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Matrix protein VP40
UniProt: Q05128
Pockets: 14 · best druggability 0.80

Structure

x-ray diffraction · 4 distinct chains · 17% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Matrix protein VP40	protein	230	15% helix, 26% strand	Q05128
B	Matrix protein VP40	protein	222	20% helix, 32% strand	Q05128
C	Matrix protein VP40	protein	233	19% helix, 30% strand	Q05128
D	Matrix protein VP40	protein	230	14% helix, 30% strand	Q05128

Pockets

14 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	308	0.80	0.91	46	empty
2	1018	0.79	0.81	85	empty
3	933	0.79	0.81	84	empty
4	697	0.75	0.80	68	empty
5	442	0.74	0.84	57	empty

Interfaces

2 interfaces between chains.

B–C · 770 Å² buried · 4 hydrogen bonds · protein-protein
A–D · 706 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

7JZT · Low resolution crystal structure of Zaire Ebola virus VP40 in space group P6422 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q05128
Elsewhere: RCSB PDB 7JZT · PDBe 7JZT · UniProt Q05128

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