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Low resolution crystal structure of zaire ebola virus VP40 in space group P6422
Analyse Low resolution crystal structure of zaire ebola virus VP40 in space group P6422 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7JZT
- Type
- protein
- Length
- 915 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Matrix protein VP40
- UniProt
- Q05128
- Pockets
- 14 · best druggability 0.80
Structure
x-ray diffraction · 4 distinct chains · 17% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Matrix protein VP40 | protein | 230 | 15% helix, 26% strand | Q05128 |
| B | Matrix protein VP40 | protein | 222 | 20% helix, 32% strand | Q05128 |
| C | Matrix protein VP40 | protein | 233 | 19% helix, 30% strand | Q05128 |
| D | Matrix protein VP40 | protein | 230 | 14% helix, 30% strand | Q05128 |
Pockets
14 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 308 | 0.80 | 0.91 | 46 | empty |
| 2 | 1018 | 0.79 | 0.81 | 85 | empty |
| 3 | 933 | 0.79 | 0.81 | 84 | empty |
| 4 | 697 | 0.75 | 0.80 | 68 | empty |
| 5 | 442 | 0.74 | 0.84 | 57 | empty |
Interfaces
2 interfaces between chains.
- B–C · 770 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 706 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 7JZT · Low resolution crystal structure of Zaire Ebola virus VP40 in space group P6422 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q05128
- Elsewhere: RCSB PDB 7JZT · PDBe 7JZT · UniProt Q05128
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