MolNFT v1 · #179246 · protein

Cftr associated ligand (cal) PDZ domain bound to peptidomimetic lycalpmb

7JZQ · Golgi-associated PDZ and coiled-coil motif-containing…: “Cftr associated ligand (cal) PDZ domain bound to peptidomimetic lycalpmb”. X-ray diffraction, 1 ligand (VU1). MolNFT v1 #179246 on GenesisL1: 3D structure, binding sites and…

PDB: 7JZQ
Type: protein
Length: 94 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Golgi-associated PDZ and coiled-coil motif-containing protein; Lycalpmb peptide core
UniProt: Q9HD26
Ligands: VU1

Structure

x-ray diffraction · 2 distinct chains · 19% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Golgi-associated PDZ and coiled-coil motif-containing protein	protein	87	21% helix, 39% strand	Q9HD26
C	Lycalpmb peptide core	protein	7	0% helix, 43% strand	—

Ligands and binding sites

VU1 · 4-[(piperidin-1-yl)methyl]benzoic acid · ligand · chains A, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–C · 471 Å² buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 covalent (covalent ligand).

Compared structures

7JZQ · CFTR Associated Ligand (CAL) PDZ domain bound to peptidomimetic LyCALPMB · the same entry in another collection · chain A against A, TM-score 1.00
Q9HD26 · AlphaFold monomer V2.0 prediction for golgi-associated PDZ and coiled-coil… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9HD26
Elsewhere: RCSB PDB 7JZQ · PDBe 7JZQ · UniProt Q9HD26

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