MolNFT v1 · #179207 · protein

Solution NMR structure of human BRD3 et complexed with NSD3(148-184) peptide

7JYN · Bromodomain-containing protein 3: “Solution NMR structure of human BRD3 et complexed with NSD3(148-184) peptide”. Solution nmr. MolNFT v1 #179207 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7JYN
Type: protein
Length: 135 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Bromodomain-containing protein 3; Histone-lysine N-methyltransferase NSD3
EC: 2.1.1.-
UniProt: Q15059, Q9BZ95

Structure

solution nmr · 2 distinct chains · 35% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Bromodomain-containing protein 3	protein	96	49% helix, 5% strand	Q15059
B	Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.-)	protein	39	0% helix, 21% strand	Q9BZ95

Interfaces

1 interface between chains.

A–B · 762 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

7JYN · Solution NMR structure of human Brd3 ET complexed with NSD3(148-184) peptide · the same entry in another collection · chain A against A, TM-score 1.00
Q15059 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 3 (Q15059) · a predicted model of the same protein · chain A against A, TM-score 0.66
Q9BZ95 · AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase NSD3 (Q9BZ95) · a predicted model of the same protein · chain B against A, TM-score 0.34

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q15059
Every structure of UniProt Q9BZ95
Elsewhere: RCSB PDB 7JYN · PDBe 7JYN · UniProt Q15059 · UniProt Q9BZ95

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