MolNFT v1 · #179112 · protein
Non-receptor protein tyrosine phosphatase SHP2 in complex with allosteric inhibitor compound 24
7JVN: “Non-receptor protein tyrosine phosphatase SHP2 in complex with allosteric inhibitor compound 24”. X-ray diffraction, 2 ligands (VKP, PO4). MolNFT v1 #179112 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7JVN
- Type
- protein
- Length
- 946 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q06124
- Ligands
- VKP, PO4
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 476 | — | Q06124 |
| B | — | protein | 470 | — | Q06124 |
Ligands and binding sites
- VKP · 6-(4-amino-4-methylpiperidin-1-yl)-3-[(2,3-dichlorophenyl)sulfanyl]pyrazin-2-amine · ligand · 2 copies · chains A, B
- PO4 · Phosphate ion · ion · 7 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7JVN · Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q06124
- Elsewhere: RCSB PDB 7JVN · PDBe 7JVN · UniProt Q06124
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