MolNFT v1 · #179043 · protein + DNA
Human complement factor B inhibited by a slow off-rate modified aptamer of 29 bases
7JTN: “Human complement factor B inhibited by a slow off-rate modified aptamer of 29 bases”. X-ray diffraction, 20 pockets (best druggability 0.80). MolNFT v1 #179043 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7JTN
- Type
- protein + DNA
- Length
- 1,464 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Complement factor B; DNA (30-mer)
- EC
- 3.4.21.47
- UniProt
- P00751
- Pockets
- 20 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 18% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Complement factor B (EC 3.4.21.47) | protein | 702 | 18% helix, 29% strand | P00751 |
| B, D | DNA (30-mer) | dna | 30 | — | — |
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 605 | 0.80 | 0.86 | 68 | empty |
| 2 | 488 | 0.80 | 0.87 | 58 | empty |
| 3 | 623 | 0.79 | 0.85 | 68 | empty |
| 4 | 379 | 0.77 | 0.87 | 42 | empty |
| 5 | 339 | 0.77 | 0.88 | 49 | empty |
Interfaces
4 interfaces between chains.
- A–B · 891 Ų buried · 15 hydrogen bonds · protein-nucleic
- C–D · 884 Ų buried · 14 hydrogen bonds · protein-nucleic
- A–C · 759 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 169 Ų buried · 0 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 30 modified, 22 disulfide (nucleotide modification, disulfide).
Compared structures
- 7JTN · Human Complement Factor B Inhibited by a Slow Off-Rate Modified Aptamer of 29 Bases · the same entry in another collection · chain A against A, TM-score 1.00
- P00751 · AlphaFold monomer V2.0 prediction for complement factor B (P00751) · a predicted model of the same protein · chain C against A, TM-score 0.59
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00751
- Elsewhere: RCSB PDB 7JTN · PDBe 7JTN · UniProt P00751
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.