MolNFT v1 · #179019 · protein
Crystal structure of the large glutamate dehydrogenase composed of 180 kda subunits from mycobacterium smegmatis
7JSR · NAD-specific glutamate dehydrogenase: “Crystal structure of the large glutamate dehydrogenase composed of 180 kda subunits from mycobacterium…”. X-ray diffraction, 20 pockets (best druggability 0.86). MolNFT v1 #179019 on GenesisL1…
- PDB
- 7JSR
- Type
- protein
- Length
- 2,973 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NAD-specific glutamate dehydrogenase
- EC
- 1.4.1.2
- UniProt
- A0R1C2
- Pockets
- 20 · best druggability 0.86
Structure
x-ray diffraction · 2 distinct chains · 53% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NAD-specific glutamate dehydrogenase (EC 1.4.1.2) | protein | 1496 | 54% helix, 12% strand | A0R1C2 |
| B | NAD-specific glutamate dehydrogenase (EC 1.4.1.2) | protein | 1477 | 53% helix, 12% strand | A0R1C2 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1094 | 0.86 | 0.87 | 156 | empty |
| 2 | 1093 | 0.84 | 0.85 | 150 | empty |
| 3 | 953 | 0.83 | 0.84 | 113 | empty |
| 4 | 436 | 0.82 | 0.90 | 81 | empty |
| 5 | 1051 | 0.81 | 0.82 | 105 | empty |
Interfaces
1 interface between chains.
- A–B · 1681 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 50 modified (engineered).
Compared structures
- 7JSR · Crystal structure of the large glutamate dehydrogenase composed of 180 kDa subunits from… · the same entry in another collection · chain A against A, TM-score 1.00
- A0R1C2 · AlphaFold monomer V2.0 prediction for NAD-specific glutamate dehydrogenase (A0R1C2) · a predicted model of the same protein · chain B against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0R1C2
- Elsewhere: RCSB PDB 7JSR · PDBe 7JSR · UniProt A0R1C2
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.