Research workbench
Crystal structure of the large glutamate dehydrogenase composed of 180 kda subunits from mycobacterium smegmatis
Analyse Crystal structure of the large glutamate dehydrogenase composed of 180 kda… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7JSR
- Type
- protein
- Length
- 2,973 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NAD-specific glutamate dehydrogenase
- EC
- 1.4.1.2
- UniProt
- A0R1C2
- Pockets
- 20 · best druggability 0.86
Structure
x-ray diffraction · 2 distinct chains · 53% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NAD-specific glutamate dehydrogenase (EC 1.4.1.2) | protein | 1496 | 54% helix, 12% strand | A0R1C2 |
| B | NAD-specific glutamate dehydrogenase (EC 1.4.1.2) | protein | 1477 | 53% helix, 12% strand | A0R1C2 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1094 | 0.86 | 0.87 | 156 | empty |
| 2 | 1093 | 0.84 | 0.85 | 150 | empty |
| 3 | 953 | 0.83 | 0.84 | 113 | empty |
| 4 | 436 | 0.82 | 0.90 | 81 | empty |
| 5 | 1051 | 0.81 | 0.82 | 105 | empty |
Interfaces
1 interface between chains.
- A–B · 1681 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 50 modified (engineered).
Compared structures
- 7JSR · Crystal structure of the large glutamate dehydrogenase composed of 180 kDa subunits from… · the same entry in another collection · chain A against A, TM-score 1.00
- A0R1C2 · AlphaFold monomer V2.0 prediction for NAD-specific glutamate dehydrogenase (A0R1C2) · a predicted model of the same protein · chain B against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0R1C2
- Elsewhere: RCSB PDB 7JSR · PDBe 7JSR · UniProt A0R1C2
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