MolNFT v1 · #178867 · protein

Crystal structure of a chimeric antigen receptor (car) scfv domain rearrangement forming a vl-vl dimer

7JO8 · 47G4-CD828Z: “Crystal structure of a chimeric antigen receptor (car) scfv domain rearrangement forming a vl-vl dimer”. X-ray diffraction, 3 pockets (best druggability 0.39). MolNFT v1 #178867 on GenesisL1: 3D structure, binding…

PDB: 7JO8
Type: protein
Length: 217 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 47G4-CD828Z
Pockets: 3 · best druggability 0.39

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	47G4-CD828Z	protein	107	6% helix, 50% strand	—
B	47G4-CD828Z	protein	110	5% helix, 48% strand	—

Ligands and binding sites

1PE · Pentaethylene glycol · additive · chains A, B
MLI · Malonate ion · additive · chains A, B
PG4 · Tetraethylene glycol · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	100	0.39	0.76	17	empty
2	77	0.39	0.78	20	1PE
3	82	0.38	0.77	19	PG4

Interfaces

1 interface between chains.

A–B · 739 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

7JO8 · Crystal structure of a Chimeric Antigen Receptor (CAR) scFv domain rearrangement forming… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7JO8 · PDBe 7JO8

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