MolNFT v1 · #178841 · protein
Cryo-EM structure of human proton-activated chloride channel pac at pH 4
7JNC: “Cryo-EM structure of human proton-activated chloride channel pac at pH 4”. Electron microscopy, 1 ligand (NAG), 16 pockets (best druggability 0.75). MolNFT v1 #178841 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7JNC
- Type
- protein
- Length
- 861 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proton-activated chloride channel
- UniProt
- Q9H813
- Ligands
- NAG
- Pockets
- 16 · best druggability 0.75
Structure
electron microscopy · 1 distinct chain · 34% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Proton-activated chloride channel | protein | 287 | 34% helix, 30% strand | Q9H813 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 15 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
16 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 90 | 0.75 | 0.97 | 35 | empty |
| 2 | 459 | 0.69 | 0.79 | 66 | empty |
| 3 | 370 | 0.62 | 0.77 | 41 | empty |
| 4 | 350 | 0.61 | 0.77 | 46 | empty |
| 5 | 337 | 0.60 | 0.77 | 40 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2114 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 2114 Ų buried · 13 hydrogen bonds · protein-protein
- B–C · 2108 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 glycan, 3 disulfide (N-glycosylation, disulfide).
Compared structures
- 7JNC · cryo-EM structure of human proton-activated chloride channel PAC at pH 4 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9H813 · AlphaFold monomer V2.0 prediction for proton-activated chloride channel (Q9H813) · a predicted model of the same protein · chain A against A, TM-score 0.73
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H813
- Elsewhere: RCSB PDB 7JNC · PDBe 7JNC · UniProt Q9H813
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