UniProt Q9H813
Proton-activated chloride channel (Q9H813)
Proton-activated chloride channel (UniProt Q9H813): 10 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 76 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9H813
- Protein
- Proton-activated chloride channel
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 76 · 6 records with a druggable one
Structures
11 records of Q9H813 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7JNA | Cryo-EM structure of human proton-activated chloride channel PAC at pH 8 | electron microscopy | A, B, C | NAG | 5 (best 0.83) |
| 7JNA | Cryo-EM structure of human proton-activated chloride channel pac at pH 8 | electron microscopy | A, B, C | NAG | — |
| 7JNC | cryo-EM structure of human proton-activated chloride channel PAC at pH 4 | electron microscopy | A, B, C | NAG | 16 (best 0.75) |
| 7JNC | Cryo-EM structure of human proton-activated chloride channel pac at pH 4 | electron microscopy | A, B, C | NAG | — |
| 7SQF | Structure of the human proton-activated chloride channel ASOR in activated conformation | electron microscopy | A, B, C | NAG | 13 (best 0.83) |
| 7SQG | Structure of the human proton-activated chloride channel ASOR in resting conformation | electron microscopy | A, B, C | NAG | 9 (best 0.83) |
| 7SQG | Structure of the human proton-activated chloride channel asor in resting conformation | electron microscopy | A, B, C | NAG | — |
| 7SQH | Structure of the human proton-activated chloride channel ASOR in desensitized conformation | electron microscopy | A, B, C | NAG | — |
| 8EQ4 | Human PAC in nanodisc at pH 4.0 with PI(4,5)P2 diC8 | electron microscopy | A, B, C | NAG, PIO | 15 (best 0.82) |
| 8FBL | Human PAC in nanodisc at pH 4.0 with PI(4,5)P2 diC8 | electron microscopy | A, B, C | NAG, PIO | 15 (best 0.82) |
| Q9H813 | AlphaFold monomer V2.0 prediction for proton-activated chloride channel (Q9H813) | predicted | A | — | 3 (best 0.44) |
Ligands
Experiment against prediction
- 7SQF chain B against the predicted model Q9H813: TM-score 0.83, RMSD 3.14 Å
- 7SQF chain A against the predicted model Q9H813: TM-score 0.83, RMSD 3.14 Å
- 7SQF chain C against the predicted model Q9H813: TM-score 0.83, RMSD 3.14 Å
- 7SQG chain C against the predicted model Q9H813: TM-score 0.82, RMSD 2.78 Å
- 7SQG chain B against the predicted model Q9H813: TM-score 0.82, RMSD 2.78 Å
- 7SQG chain A against the predicted model Q9H813: TM-score 0.82, RMSD 2.78 Å
- 7SQG chain A against the predicted model Q9H813: TM-score 0.82, RMSD 2.78 Å
- 7JNA chain A against the predicted model Q9H813: TM-score 0.79, RMSD 3.15 Å
- 7JNA chain A against the predicted model Q9H813: TM-score 0.79, RMSD 3.15 Å
- 7JNA chain B against the predicted model Q9H813: TM-score 0.79, RMSD 3.15 Å
Elsewhere
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