MolNFT v1 · #178716 · protein
Crystal structure of the second bromodomain (BD2) of human TAF1 bound to atr kinase inhibitor AZ20
7JJG · Transcription initiation factor tfiid subunit 1: “Crystal structure of the second bromodomain (BD2) of human TAF1 bound to atr kinase inhibitor AZ20”. X-ray diffraction, 1 ligand (VCD), 1 pocket (best druggability 0.51). MolNFT v1…
- PDB
- 7JJG
- Type
- protein
- Length
- 137 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription initiation factor tfiid subunit 1
- EC
- 2.3.1.48, 2.7.11.1
- UniProt
- P21675
- Ligands
- VCD
- Pockets
- 1 · best druggability 0.51
Structure
x-ray diffraction · 1 distinct chain · 73% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription initiation factor tfiid subunit 1 (EC 2.3.1.48, 2.7.11.1) | protein | 137 | 73% helix, 0% strand | P21675 |
Ligands and binding sites
- VCD · 4-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole · ligand · chains A
- EDO · 1,2-ethanediol · additive · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 111 | 0.51 | 0.81 | 22 | VCD |
Compared structures
- 7JJG · Crystal structure of the second bromodomain (BD2) of human TAF1 bound to ATR kinase… · the same entry in another collection · chain A against A, TM-score 1.00
- P21675 · AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 1… · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21675
- Elsewhere: RCSB PDB 7JJG · PDBe 7JJG · UniProt P21675
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