MolNFT v1 · #178514 · protein

Luteinizing HORMONE/CHORIOGONADOTROPIN receptor

7FIJ · Lutropin-choriogonadotropic hormone receptor: “Luteinizing HORMONE/CHORIOGONADOTROPIN receptor”. Electron microscopy, 3 pockets (best druggability 0.88). MolNFT v1 #178514 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 7FIJ
Type: protein
Length: 561 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lutropin-choriogonadotropic hormone receptor
UniProt: P22888
Pockets: 3 · best druggability 0.88

Structure

electron microscopy · 1 distinct chain · 39% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
R	Lutropin-choriogonadotropic hormone receptor	protein	561	39% helix, 10% strand	P22888

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1111	0.88	0.89	149	empty
2	1156	0.84	0.85	155	empty
3	52	0.45	0.84	15	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

7FIJ · luteinizing hormone/choriogonadotropin receptor · the same entry in another collection · chain R against R, TM-score 1.00
P22888 · AlphaFold monomer V2.0 prediction for lutropin-choriogonadotropic hormone receptor… · a predicted model of the same protein · chain R against A, TM-score 0.72

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22888
Elsewhere: RCSB PDB 7FIJ · PDBe 7FIJ · UniProt P22888

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