MolNFT v1 · #178419 · protein

Human serum transferrin with five osmium binding sites

7FFM · Serotransferrin: “Human serum transferrin with five osmium binding sites”. X-ray diffraction, 3 ligands (NTA, OS, 4TI), 7 pockets (best druggability 0.79). MolNFT v1 #178419 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 7FFM
Type: protein
Length: 649 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Serotransferrin
UniProt: P02787
Ligands: NTA, OS, 4TI
Pockets: 7 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Serotransferrin	protein	649	37% helix, 20% strand	P02787

Ligands and binding sites

NTA · Nitrilotriacetic acid · ligand · chains A
OS · Osmium ion · metal · 5 copies · chains A
4TI · Titanium ion · metal · chains A
MLI · Malonate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	832	0.79	0.82	80	MLI
2	735	0.75	0.80	53	empty
3	188	0.57	0.80	20	empty
4	159	0.44	0.75	29	empty
5	87	0.37	0.76	20	empty

Modifications

Observed in the structure: 17 disulfide (disulfide).

Compared structures

7FFM · Human serum transferrin with five osmium binding sites · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02787
Elsewhere: RCSB PDB 7FFM · PDBe 7FFM · UniProt P02787

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.