MolNFT v1 · #17808 · protein
Solution structure of the CITED2 transactivation domain in complex with the P300 CH1 domain
1P4Q · CBP/P300-interacting transactivator 2: “Solution structure of the CITED2 transactivation domain in complex with the P300 CH1 domain”. Solution nmr, 1 ligand (ZN), 3 pockets (best druggability 0.39). MolNFT v1 #17808 on GenesisL1: 3D…
- PDB
- 1P4Q
- Type
- protein
- Length
- 153 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CBP/P300-interacting transactivator 2; E1A-associated protein P300
- EC
- 2.3.1.48
- UniProt
- Q99967, Q09472
- Ligands
- ZN
- Pockets
- 3 · best druggability 0.39
Structure
solution nmr · 2 distinct chains · 44% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CBP/P300-interacting transactivator 2 | protein | 52 | 23% helix, 0% strand | Q99967 |
| B | E1A-associated protein P300 (EC 2.3.1.48) | protein | 101 | 55% helix, 0% strand | Q09472 |
Ligands and binding sites
- ZN · Zinc ion · metal · 3 copies · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 76 | 0.39 | 0.78 | 20 | empty |
| 2 | 56 | 0.30 | 0.76 | 16 | empty |
| 3 | 56 | 0.29 | 0.75 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 2183 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 1P4Q · Solution structure of the CITED2 transactivation domain in complex with the p300 CH1… · the same entry in another collection · chain A against A, TM-score 1.00
- Q09472 · AlphaFold monomer V2.0 prediction for histone acetyltransferase P300 (Q09472) · a predicted model of the same protein · chain B against A, TM-score 0.73
- Q99967 · AlphaFold monomer V2.0 prediction for CBP/P300-interacting transactivator 2 (Q99967) · a predicted model of the same protein · chain A against A, TM-score 0.59
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99967
- Every structure of UniProt Q09472
- Elsewhere: RCSB PDB 1P4Q · PDBe 1P4Q · UniProt Q99967 · UniProt Q09472
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