MolNFT v1 · #177951 · protein

Complex structure of athppd with inhibitor Y15832

7EZQ · 4-hydroxyphenylpyruvate dioxygenase: “Complex structure of athppd with inhibitor Y15832”. X-ray diffraction, 2 ligands (0O0, CO), 3 pockets (best druggability 0.69). MolNFT v1 #177951 on GenesisL1: 3D structure, binding sites and…

PDB: 7EZQ
Type: protein
Length: 382 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 4-hydroxyphenylpyruvate dioxygenase
EC: 1.13.11.27
UniProt: P93836
Ligands: 0O0, CO
Pockets: 3 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27)	protein	382	30% helix, 34% strand	P93836

Ligands and binding sites

0O0 · 6-(1,3-dimethyl-5-oxidanyl-pyrazol-4-yl)carbonyl-1,5-dimethyl-3-(2-methylphenyl)quinazoline-2,4-dione · ligand · chains A
CO · Cobalt (II) ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	433	0.69	0.80	43	0O0
2	73	0.35	0.76	12	empty
3	51	0.27	0.75	19	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

7EZQ · Complex structure of AtHPPD with inhibitor Y15832 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P93836
Elsewhere: RCSB PDB 7EZQ · PDBe 7EZQ · UniProt P93836

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