MolNFT v1 · #177913 · protein
PORTAL
7EY8 · Portal protein: “PORTAL”. Electron microscopy, 20 pockets (best druggability 0.83). MolNFT v1 #177913 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7EY8
- Type
- protein
- Length
- 6,300 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Portal protein
- UniProt
- P03728
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 1 distinct chain · 48% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L | Portal protein | protein | 525 | 48% helix, 11% strand | P03728 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 873 | 0.83 | 0.85 | 72 | empty |
| 2 | 828 | 0.82 | 0.85 | 70 | empty |
| 3 | 1031 | 0.82 | 0.83 | 79 | empty |
| 4 | 1028 | 0.82 | 0.83 | 76 | empty |
| 5 | 594 | 0.82 | 0.87 | 47 | empty |
Interfaces
24 interfaces between chains.
- K–L · 5973 Ų buried · 61 hydrogen bonds · protein-protein
- E–F · 5970 Ų buried · 64 hydrogen bonds · protein-protein
- J–K · 5964 Ų buried · 66 hydrogen bonds · protein-protein
- A–L · 5964 Ų buried · 58 hydrogen bonds · protein-protein
- A–B · 5963 Ų buried · 61 hydrogen bonds · protein-protein
Compared structures
- 7EY8 · portal · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03728
- Elsewhere: RCSB PDB 7EY8 · PDBe 7EY8 · UniProt P03728
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