MolNFT v1 · #177912 · protein

Bacteriophage T7 tail complex

7EY7 · Tail fiber protein: “Bacteriophage T7 tail complex”. Electron microscopy, 20 pockets (best druggability 0.84). MolNFT v1 #177912 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7EY7
Type: protein
Length: 9,744 residues
Chains: 42
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tail fiber protein; Tail tubular protein GP12; Internal virion protein GP14; Tail tubular…
UniProt: P03748, P03747, P03724, P03746
Pockets: 20 · best druggability 0.84

Structure

electron microscopy · 5 distinct chains · 23% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p, q, r	Tail fiber protein	protein	115	21% helix, 23% strand	P03748
s, t, u, v, w, x	Tail tubular protein GP12	protein	789	5% helix, 34% strand	P03747
A, B, C, D, E, F	Internal virion protein GP14	protein	102	94% helix, 0% strand	P03724
M, O, Q, S, U, W	Tail tubular protein GP11	protein	195	42% helix, 13% strand	P03746
N, P, R, T, V, X	Tail tubular protein GP11	protein	193	42% helix, 13% strand	P03746

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1140	0.84	0.85	121	empty
2	882	0.83	0.85	83	empty
3	1043	0.83	0.84	99	empty
4	815	0.82	0.85	72	empty
5	842	0.82	0.85	79	empty

Interfaces

126 interfaces between chains.

U–V · 1843 Å² buried · 15 hydrogen bonds · protein-protein
S–T · 1831 Å² buried · 18 hydrogen bonds · protein-protein
W–X · 1830 Å² buried · 17 hydrogen bonds · protein-protein
Q–R · 1830 Å² buried · 17 hydrogen bonds · protein-protein
O–P · 1817 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

7EY7 · bacteriophage T7 tail complex · the same entry in another collection · chain a against a, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03748
Every structure of UniProt P03747
Every structure of UniProt P03724
Every structure of UniProt P03746
Elsewhere: RCSB PDB 7EY7 · PDBe 7EY7 · UniProt P03748 · UniProt P03747 · UniProt P03724 · UniProt P03746

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