MolNFT v1 · #177901 · protein

Thermomicrobium roseum sarcosine oxidase mutant - S320R

7EXS: “Thermomicrobium roseum sarcosine oxidase mutant - S320R”. X-ray diffraction, 3 ligands (FAD, CL, PO4), 3 pockets (best druggability 0.84). MolNFT v1 #177901 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7EXS
Type: protein
Length: 372 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sarcosine oxidase
EC: 1.5.3.1
UniProt: B9L163
Ligands: FAD, CL, PO4
Pockets: 3 · best druggability 0.84

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sarcosine oxidase (EC 1.5.3.1)	protein	372	31% helix, 31% strand	B9L163

Ligands and binding sites

FAD · Flavin-adenine dinucleotide · ligand · chains A
CL · Chloride ion · ion · 7 copies · chains A
PO4 · Phosphate ion · ion · 3 copies · chains A
GOL · Glycerol · additive · 6 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	448	0.84	0.91	72	FAD, GOL, CL
2	66	0.36	0.78	13	empty
3	64	0.32	0.76	16	empty

Modifications

Observed in the structure: 1 cofactor (flavinylation).

Compared structures

7EXS · Thermomicrobium roseum sarcosine oxidase mutant - S320R · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B9L163
Elsewhere: RCSB PDB 7EXS · PDBe 7EXS · UniProt B9L163

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