MolNFT v1 · #177758 · protein
Crystal structure of the complex formed by wolbachia cytoplasmic incompatibility factors cina and cinb from wpip
7ET0 · Bacteria factor B: “Crystal structure of the complex formed by wolbachia cytoplasmic incompatibility factors cina and cinb from…”. X-ray diffraction, 20 pockets (best druggability 0.89). MolNFT v1 #177758 on GenesisL1: 3D structure…
- PDB
- 7ET0
- Type
- protein
- Length
- 2,158 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bacteria factor B; Bacteria factor a
- UniProt
- B3CP74, B3CP73
- Pockets
- 20 · best druggability 0.89
Structure
x-ray diffraction · 4 distinct chains · 49% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Bacteria factor B | protein | 665 | 37% helix, 26% strand | B3CP74 |
| B | Bacteria factor a | protein | 405 | 71% helix, 2% strand | B3CP73 |
| C | Bacteria factor B | protein | 684 | 36% helix, 27% strand | B3CP74 |
| D | Bacteria factor a | protein | 404 | 69% helix, 2% strand | B3CP73 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1076 | 0.89 | 0.90 | 141 | empty |
| 2 | 779 | 0.87 | 0.90 | 89 | empty |
| 3 | 502 | 0.85 | 0.91 | 73 | empty |
| 4 | 941 | 0.74 | 0.78 | 69 | empty |
| 5 | 202 | 0.70 | 0.87 | 30 | empty |
Interfaces
5 interfaces between chains.
- C–D · 2659 Ų buried · 48 hydrogen bonds · protein-protein
- A–B · 2649 Ų buried · 41 hydrogen bonds · protein-protein
- B–C · 439 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 426 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 102 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 7ET0 · Crystal structure of the complex formed by Wolbachia cytoplasmic incompatibility factors… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B3CP74
- Every structure of UniProt B3CP73
- Elsewhere: RCSB PDB 7ET0 · PDBe 7ET0 · UniProt B3CP74 · UniProt B3CP73
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