MolNFT v1 · #177674 · protein
Crystal structure of monooxygenase TET(X4) with tigecycline
7EPW · Flavin-dependent monooxygenase: “Crystal structure of monooxygenase TET(X4) with tigecycline”. X-ray diffraction, 2 ligands (FDA, T1C), 1 pocket (best druggability 0.78). MolNFT v1 #177674 on GenesisL1: 3D structure, binding sites…
- PDB
- 7EPW
- Type
- protein
- Length
- 373 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Flavin-dependent monooxygenase
- EC
- 1.14.13.-
- UniProt
- A0A3T0V9Y5
- Ligands
- FDA, T1C
- Pockets
- 1 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 33% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Flavin-dependent monooxygenase (EC 1.14.13.-) | protein | 373 | 33% helix, 25% strand | A0A3T0V9Y5 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1172 | 0.78 | 0.79 | 90 | FDA, T1C |
Compared structures
- 7EPW · Crystal structure of monooxygenase Tet(X4) with tigecycline · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A3T0V9Y5
- Elsewhere: RCSB PDB 7EPW · PDBe 7EPW · UniProt A0A3T0V9Y5
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