MolNFT v1 · #177644 · protein
Crystal structure of ZYG11B bound to gste degron
7EP0 · Protein zyg-11 homolog B: “Crystal structure of ZYG11B bound to gste degron”. X-ray diffraction, 1 ligand (CGO), 1 pocket (best druggability 0.75). MolNFT v1 #177644 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7EP0
- Type
- protein
- Length
- 500 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein zyg-11 homolog B
- UniProt
- Q9C0D3
- Ligands
- CGO
- Pockets
- 1 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 73% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Protein zyg-11 homolog B | protein | 250 | 73% helix, 1% strand | Q9C0D3 |
Ligands and binding sites
- CGO · sodium 3,3'-(1E,1'E)-biphenyl-4,4'-diylbis(diazene-2,1-diyl)bis(4-aminonaphthalene-1-sulfonate) · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 985 | 0.75 | 0.78 | 69 | CGO |
Interfaces
1 interface between chains.
- A–B · 1078 Ų buried · 25 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 modified (engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9C0D3
- Elsewhere: RCSB PDB 7EP0 · PDBe 7EP0 · UniProt Q9C0D3
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