MolNFT v1 · #177451 · protein

Human histidine decarboxylase mutant Y334F

7EIX: “Human histidine decarboxylase mutant Y334F”. X-ray diffraction, 2 ligands (PLP, SO4), 12 pockets (best druggability 0.65). MolNFT v1 #177451 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7EIX
Type: protein
Length: 931 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Histidine decarboxylase
EC: 4.1.1.22
UniProt: P19113
Ligands: PLP, SO4
Pockets: 12 · best druggability 0.65

Structure

x-ray diffraction · 2 distinct chains · 51% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Histidine decarboxylase (EC 4.1.1.22)	protein	467	50% helix, 13% strand	P19113
B	Histidine decarboxylase (EC 4.1.1.22)	protein	464	51% helix, 14% strand	P19113

Ligands and binding sites

PLP · Pyridoxal-5'-phosphate · ligand · 2 copies · chains A, B
SO4 · Sulfate ion · ion · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

12 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	312	0.65	0.81	52	PLP
2	281	0.63	0.80	47	PLP
3	147	0.52	0.80	24	empty
4	101	0.47	0.80	23	empty
5	128	0.42	0.75	24	empty

Interfaces

1 interface between chains.

A–B · 6036 Å² buried · 81 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 cofactor, 2 modified (pyridoxal phosphate Schiff base, oxidation).

Compared structures

7EIX · Human histidine decarboxylase mutant Y334F · the same entry in another collection · chain A against A, TM-score 1.00
P19113 · AlphaFold monomer V2.0 prediction for histidine decarboxylase (P19113) · a predicted model of the same protein · chain B against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19113
Elsewhere: RCSB PDB 7EIX · PDBe 7EIX · UniProt P19113

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.