UniProt P19113
Histidine decarboxylase (P19113)
Histidine decarboxylase (UniProt P19113), EC 4.1.1.22: 8 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 34 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P19113
- Protein
- Histidine decarboxylase
- EC
- 4.1.1.22
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 34 · 3 records with a druggable one
Structures
9 records of P19113 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4E1O | Human histidine decarboxylase complex with Histidine methyl ester (HME) | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4E1O | Human histidine decarboxylase complex with histidine methyl ester (hme) | x-ray diffraction | A, B, C, D, E, F | — | — |
| 7EIW | Human histidine decarboxylase mutant Y334F reacted with histidine | x-ray diffraction | A, B | PLP | 10 (best 0.69) |
| 7EIW | Human histidine decarboxylase mutant Y334F reacted with histidine | x-ray diffraction | A, B | PLP | — |
| 7EIX | Human histidine decarboxylase mutant Y334F | x-ray diffraction | A, B | PLP, SO4 | 12 (best 0.65) |
| 7EIX | Human histidine decarboxylase mutant Y334F | x-ray diffraction | A, B | PLP, SO4 | — |
| 7EIY | Human histidine decarboxylase mutant Y334F soaking with histidine | x-ray diffraction | A, B | PLP, HIS, SO4 | 12 (best 0.67) |
| 7EIY | Human histidine decarboxylase mutant Y334F soaking with histidine | x-ray diffraction | A, B | PLP, SO4 | — |
| P19113 | AlphaFold monomer V2.0 prediction for histidine decarboxylase (P19113) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7EIX chain B against the predicted model P19113: TM-score 1.00, RMSD 0.36 Å
- 7EIX chain B against the predicted model P19113: TM-score 1.00, RMSD 0.36 Å
- 4E1O chain A against the predicted model P19113: TM-score 1.00, RMSD 0.44 Å
- 4E1O chain A against the predicted model P19113: TM-score 1.00, RMSD 0.44 Å
- 4E1O chain B against the predicted model P19113: TM-score 1.00, RMSD 0.46 Å
- 4E1O chain B against the predicted model P19113: TM-score 1.00, RMSD 0.46 Å
- 7EIY chain B against the predicted model P19113: TM-score 1.00, RMSD 0.52 Å
- 4E1O chain E against the predicted model P19113: TM-score 1.00, RMSD 0.44 Å
- 4E1O chain E against the predicted model P19113: TM-score 1.00, RMSD 0.44 Å
- 7EIY chain B against the predicted model P19113: TM-score 1.00, RMSD 0.63 Å
Elsewhere
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